As is the case elsewhere in the world, there is evidence that some central and eastern North America earthquakes have been triggered or caused by human activities that have altered the stress conditions in earth’s crust sufficiently to induce faulting. Activities that have induced felt earthquakes in some geologic environments have included impoundment of water behind dams, injection of fluid into the earth’s crust, extraction of fluid or gas, and removal of rock in mining or quarrying operations. In much of eastern and central North America, the number of earthquakes suspected of having been induced is much smaller than the number of natural earthquakes, but in some regions, such as the south-central states of the U.S., a significant majority of recent earthquakes are thought by many seismologists to have been human-induced. Even within areas with many human-induced earthquakes, however, the activity that seems to induce seismicity at one location may be taking place at many other locations without inducing felt earthquakes. In addition, regions with frequent induced earthquakes may also be subject to damaging earthquakes that would have occurred independently of human activity. Making a strong scientific case for a causative link between a particular human activity and a particular sequence of earthquakes typically involves special studies devoted specifically to the question. Such investigations usually address the process by which the suspected triggering activity might have significantly altered stresses in the bedrock at the earthquake source, and they commonly address the ways in which the characteristics of the suspected human-triggered earthquakes differ from the characteristics of natural earthquakes in the region.